Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNB1 | Q14721 | 9/20 | 0.62 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CTSA | P10619 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28255847 | 0.90 | KCNB1 (0.52) | KCNB1KCNA5CTSA | |
| SCHEMBL28406263 | 0.88 | KCNB1 (0.82) | KCNB1KCNA5 | |
| SCHEMBL29793608 | 0.88 | KCNB1 (0.82) | KCNB1KCNA5 | |
| SCHEMBL29793719 | 0.82 | KCNB1 (0.58) | KCNB1KCNA5ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL28890733 | 0.79 | KCNB1 (0.75) | KCNB1KCNA5 | |
| SCHEMBL28403268 | 0.78 | KCNB1 (0.76) | KCNB1KCNA5CTSA | |
| SCHEMBL28402269 | 0.77 | KCNB1 (0.85) | KCNB1KCNA5 | |
| SCHEMBL28413299 | 0.77 | KCNB1 (0.54) | KCNB1KCNA5CTSA | |
| SCHEMBL28413534 | 0.77 | KCNB1 (0.74) | KCNB1KCNA5ALDH1A1CTSA | |
| SCHEMBL28408076 | 0.77 | KCNB1 (0.84) | KCNB1KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108929263-B | Arylamide Kv2.1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2022-07-22 | — | — | CN | disclosed |