Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 4/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18151470 | 1.00 | TNF (0.42) | TNFEGFRMTOR | |
| SCHEMBL18150889 | 0.87 | TNF (0.47) | TNFMTOR | |
| SCHEMBL18151394 | 0.87 | TNF (0.47) | TNFMTOR | |
| SCHEMBL18151826 | 0.85 | EGFR (0.35) | TNFEGFRMTOR | |
| SCHEMBL18150789 | 0.85 | TNF (0.43) | TNFMTOR | |
| SCHEMBL18151222 | 0.83 | TNF (0.44) | TNFMTOR | |
| SCHEMBL29795004 | 0.83 | TNF (0.44) | TNFMTOR | |
| SCHEMBL29795029 | 0.83 | TNF (0.45) | TNFMTOR | |
| SCHEMBL18150324 | 0.83 | TNF (0.45) | TNFMTOR | |
| SCHEMBL18151698 | 0.80 | NTRK1 (0.41) | TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4493221-A2 | TARGETED BIFUNCTIONAL DEGRADERS | Yale University (US) | 2025-01-22 | — | — | EP | disclosed |
| CN-119212727-A | Targeted bifunctional degradants | 耶鲁大学 | 2024-12-27 | — | — | CN | disclosed |
| WO-2024182772-A2 | MANNOSE 6-PHOSPHATE RECEPTOR BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS | AVILAR THERAPEUTICS, INC. (US) | 2024-09-06 | — | — | WO | disclosed |
| WO-2023178199-A2 | TARGETED BIFUNCTIONAL DEGRADERS | YALE UNIVERSITY (US) | 2023-09-21 | — | — | WO | disclosed |
| EP-4041262-A1 | TARGETED BIFUNCTIONAL DEGRADERS | Yale University (US) | 2022-08-17 | — | — | EP | disclosed |