Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.32 |
| ▸ | MTOR | P42345 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18151261 | 1.00 | TNF (0.37) | TNFPIK3CAPIK3R1MTORMAPT | |
| SCHEMBL20313869 | 0.89 | TNF (0.38) | TNFPIK3CAMTORMAPTPIK3CD | |
| SCHEMBL29794887 | 0.88 | TNF (0.38) | TNFMAPT | |
| SCHEMBL18151635 | 0.88 | TNF (0.38) | TNFMAPT | |
| SCHEMBL18151312 | 0.85 | PIK3CA (0.35) | TNFPIK3CAPIK3R1MTORMAPT | |
| SCHEMBL29795035 | 0.85 | PIK3CA (0.35) | TNFPIK3CAPIK3R1MTORMAPT | |
| SCHEMBL18159853 | 0.84 | TNF (0.37) | TNF | |
| SCHEMBL29794949 | 0.83 | AKT1 (0.33) | TNFPIK3CAPIK3R1MTORMAPT | |
| SCHEMBL18151076 | 0.83 | AKT1 (0.33) | TNFPIK3CAPIK3R1MTORMAPT | |
| SCHEMBL18151320 | 0.82 | TNF (0.34) | TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4493221-A2 | TARGETED BIFUNCTIONAL DEGRADERS | Yale University (US) | 2025-01-22 | — | — | EP | disclosed |
| WO-2024182772-A2 | MANNOSE 6-PHOSPHATE RECEPTOR BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS | AVILAR THERAPEUTICS, INC. (US) | 2024-09-06 | — | — | WO | disclosed |
| WO-2023178199-A2 | TARGETED BIFUNCTIONAL DEGRADERS | YALE UNIVERSITY (US) | 2023-09-21 | — | — | WO | disclosed |
| EP-4041262-A1 | TARGETED BIFUNCTIONAL DEGRADERS | Yale University (US) | 2022-08-17 | — | — | EP | disclosed |