SCHEMBL29796103

SCHEMBL29796103

Cc1ccc(N=C=O)c(C)c1Cl

nearest known ligand 0.55

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.55
TRPA1 O75762 1/20 0.48
TDP1 Q9NUW8 2/20 0.38
ALDH1A1 P00352 1/20 0.38
HPGD P15428 1/20 0.38
GABRA1 P14867 1/20 0.34
GABRB2 P47870 1/20 0.34
MAPK1 P28482 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23213309 1.00 CYP3A4 (0.55) CYP3A4TRPA1TDP1ALDH1A1HPGD
SCHEMBL9551404 0.86 CYP3A4 (0.50) CYP3A4TRPA1TDP1ALDH1A1HPGD
SCHEMBL29796026 0.86 CYP3A4 (0.50) CYP3A4TRPA1TDP1ALDH1A1HPGD
SCHEMBL11475560 0.84 CYP3A4 (0.55) CYP3A4TRPA1TDP1ALDH1A1HPGD
SCHEMBL10316539 0.82 CYP3A4 (0.47) CYP3A4TRPA1TDP1ALDH1A1HPGD
SCHEMBL29606267 0.81 CYP3A4 (0.61) CYP3A4TRPA1TDP1ALDH1A1HPGD
SCHEMBL11608345 0.81 CYP3A4 (0.61) CYP3A4TRPA1TDP1ALDH1A1HPGD
SCHEMBL31162473 0.80 CYP3A4 (0.73) CYP3A4TRPA1TDP1ALDH1A1HPGD
SCHEMBL110655 0.80 CYP3A4 (0.73) CYP3A4TRPA1TDP1ALDH1A1HPGD
SCHEMBL10316854 0.78 CYP3A4 (0.47) CYP3A4TRPA1TDP1ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4313047-A1 PHARMACEUTICAL COMPOSITIONS FOR USE IN THE PREVENTION AND TREATMENT OF A DISEASE OR DISORDER CAUSED BY OR ASSOCIATED WITH ONE OR MORE PREMATURE TERMINATION CODONS Monte Rosa Therapeutics, Inc. (US) 2024-02-07 EP disclosed
WO-2022200857-A1 PHARMACEUTICAL COMPOSITIONS FOR USE IN THE PREVENTION AND TREATMENT OF A DISEASE OR DISORDER CAUSED BY OR ASSOCIATED WITH ONE OR MORE PREMATURE TERMINATION CODONS MONTE ROSA THERAPEUTICS AG (CH) 2022-09-29 WO disclosed
EP-4041231-A1 ISOINDOLINONE COMPOUNDS Monte Rosa Therapeutics AG (CH) 2022-08-17 EP disclosed