Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 8/20 | 1.00 |
| ▸ | SMARCA4 | P51532 | 8/20 | 0.67 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22794545 | 1.00 | PBRM1 (1.00) | PBRM1SMARCA4SMARCA2POLBPARP1 | |
| SCHEMBL22794561 | 0.88 | PBRM1 (0.78) | PBRM1SMARCA4SMARCA2POLB | |
| SCHEMBL22794553 | 0.87 | PBRM1 (0.78) | PBRM1SMARCA4SMARCA2POLBPARP1 | |
| SCHEMBL22794562 | 0.86 | PBRM1 (0.75) | PBRM1SMARCA4SMARCA2POLB | |
| SCHEMBL22794538 | 0.82 | PBRM1 (0.98) | PBRM1SMARCA4SMARCA2POLBCCR3 | |
| SCHEMBL22794539 | 0.81 | PBRM1 (1.00) | PBRM1SMARCA4SMARCA2POLBCCR3 | |
| SCHEMBL22794478 | 0.81 | PBRM1 (1.00) | PBRM1SMARCA4SMARCA2POLBCCR3 | |
| SCHEMBL22794479 | 0.81 | PBRM1 (1.00) | PBRM1SMARCA4SMARCA2POLBPARP1 | |
| SCHEMBL22794541 | 0.80 | SMARCA4 (1.00) | PBRM1SMARCA4SMARCA2CCR3 | |
| SCHEMBL22794480 | 0.79 | PBRM1 (0.70) | PBRM1SMARCA4SMARCA2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022174085-A1 | SMALL MOLECULE INHIBITORS OF PBRM1-BD2 | THE MEDICAL COLLEGE OF WISCONSIN, INC. (US) | 2022-08-18 | — | — | WO | disclosed |