Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.81 |
| ▸ | PARP1 | P09874 | 6/20 | 0.68 |
| ▸ | POLB | P06746 | 3/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL834012 | 0.93 | PARP1 (0.78) | PARP2PARP1POLBHTTESR2 | |
| SCHEMBL15661314 | 0.89 | PARP2 (1.00) | PARP2PARP1POLBHTTESR2 | |
| SCHEMBL29802800 | 0.88 | PARP1 (0.82) | PARP2PARP1POLBHTTESR2 | |
| SCHEMBL835366 | 0.86 | PARP2 (0.93) | PARP2PARP1POLBHTTESR2 | |
| SCHEMBL834519 | 0.81 | PARP1 (1.00) | PARP2PARP1POLBHTTESR2 | |
| SCHEMBL1861959 | 0.80 | PARP1 (0.79) | PARP2PARP1POLBHTTESR2 | |
| SCHEMBL29802704 | 0.79 | PARP1 (0.69) | PARP2PARP1 | |
| SCHEMBL1882436 | 0.79 | PARP2 (0.81) | PARP2PARP1POLBHTTESR2 | |
| SCHEMBL6128731 | 0.79 | PARP2 (0.81) | PARP2PARP1POLBHTTESR2 | |
| SCHEMBL1882438 | 0.79 | PARP2 (0.81) | PARP2PARP1POLBHTTESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11773064-B2 | 4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2023-10-03 | — | — | US | disclosed |
| US-20220363636-A1 | 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2022-11-17 | — | — | US | disclosed |
| US-11420940-B2 | 4-carboxamido-isoindolinone derivatives as selective parp-1 inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2022-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11773064-B2 | 4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors | PARP1, PARP2, PARP12 | PARP2 2/4885PARP1 1/4885POLB 159/4885 |
| US-11420940-B2 | 4-carboxamido-isoindolinone derivatives as selective parp-1 inhibitors | PARP1, PARP2, PARP11 | PARP2 2/4885PARP1 1/4885POLB 151/4885 |
| US-20220363636-A1 | 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS | PARP1, PARP2, PARP12 | PARP2 2/4885PARP1 1/4885POLB 165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.