SCHEMBL29811874

SCHEMBL29811874

COc1cc2nccc(Oc3ncc(N)cc3F)c2cc1OC

nearest known ligand 0.58

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ PDGFRB P09619 1/20 0.54
▸ PDGFRA P16234 1/20 0.54
▸ AXL P30530 1/20 0.50
▸ FGFR2 P21802 3/20 0.49
▸ EGFR P00533 1/20 0.49
▸ KDR P35968 1/20 0.48
▸ KIT P10721 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23147176 1.00 PDGFRB (0.54) PDGFRBPDGFRAAXLFGFR2EGFR
SCHEMBL4462225 0.86 PDGFRA (0.56) PDGFRBPDGFRAFGFR2EGFRKDR
SCHEMBL22265563 0.85 AXL (0.54) PDGFRAAXLFGFR2KDRKIT
SCHEMBL14967538 0.84 PDGFRB (0.57) PDGFRBPDGFRAAXLFGFR2EGFR
SCHEMBL166914 0.83 AXL (0.67) PDGFRBPDGFRAAXLFGFR2KDR
SCHEMBL17035605 0.82 AXL (0.66) PDGFRBPDGFRAAXLFGFR2KDR
Hydrochloric Acid SCHEMBL30388215 0.82 AXL (0.66) PDGFRBPDGFRAAXLFGFR2KDR
Hydrochloric Acid SCHEMBL21776567 0.82 AXL (0.66) PDGFRBPDGFRAAXLFGFR2KDR
SCHEMBL31554494 0.82 KIT (0.45) PDGFRBPDGFRAEGFRKDRKIT
SCHEMBL21753513 0.81 PDGFRB (0.59) PDGFRBPDGFRAFGFR2EGFRKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025096463-A1 PLK4 MODULATORS VIBLIOME THERAPEUTICS, LLC (US) 2025-05-08 — — WO disclosed
CN-114787144-A Pyridone compounds and methods for modulating protein kinases 埃克塞里艾克西斯公司 2022-07-22 — — CN disclosed
Send feedback