Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | ALB | P02768 | 1/20 | 0.44 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.44 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 3/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23146871 | 1.00 | TTR (0.44) | TTRHPGDHSD17B10MEN1LMNA | |
| SCHEMBL29812407 | 0.90 | NOTUM (0.39) | TTRHPGDHSD17B10MEN1LMNA | |
| SCHEMBL23147123 | 0.90 | NOTUM (0.39) | TTRHPGDHSD17B10MEN1LMNA | |
| SCHEMBL23147433 | 0.81 | NOTUM (0.42) | HPGDMEN1LMNAKMT2AKDM4E | |
| SCHEMBL29811081 | 0.78 | MAP2K1 (0.39) | MEN1KMT2AKDM4EMAP2K1MAP2K2 | |
| SCHEMBL25207091 | 0.76 | DHODH (0.40) | MEN1LMNAKMT2ADHODHNOTUM | |
| SCHEMBL30174230 | 0.76 | DHODH (0.40) | MEN1LMNAKMT2ADHODHNOTUM | |
| SCHEMBL23147172 | 0.75 | POLB (0.39) | TTRHPGDHSD17B10MEN1LMNA | |
| SCHEMBL29765072 | 0.75 | POLB (0.39) | TTRHPGDHSD17B10MEN1LMNA | |
| SCHEMBL23146682 | 0.72 | TOP2A (0.48) | HPGDHSD17B10MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114787144-A | Pyridone compounds and methods for modulating protein kinases | 埃克塞里艾克西斯公司 | 2022-07-22 | — | — | CN | disclosed |