Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.79 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.79 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.72 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.72 |
| ▸ | AURKA | O14965 | 4/20 | 0.71 |
| ▸ | CTSC | P53634 | 5/20 | 0.70 |
| ▸ | BCL6 | P41182 | 1/20 | 0.68 |
| ▸ | CDK2 | P24941 | 4/20 | 0.65 |
| ▸ | IGF1R | P08069 | 2/20 | 0.65 |
| ▸ | JAK3 | P52333 | 2/20 | 0.65 |
| ▸ | PLK4 | O00444 | 1/20 | 0.65 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.65 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.65 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.65 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.65 |
| ▸ | INSR | P06213 | 1/20 | 0.65 |
| ▸ | LCK | P06239 | 1/20 | 0.65 |
| ▸ | FYN | P06241 | 1/20 | 0.65 |
| ▸ | CDK1 | P06493 | 1/20 | 0.65 |
| ▸ | FES | P07332 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15391316 | 1.00 | JAK2 (0.79) | JAK2LRRK2ALKCDK19AURKA | |
| SCHEMBL24842785 | 0.91 | CTSC (0.71) | JAK2LRRK2ALKCDK19AURKA | |
| SCHEMBL29816755 | 0.91 | CTSC (0.71) | JAK2LRRK2ALKCDK19AURKA | |
| SCHEMBL12505113 | 0.89 | JAK2 (0.69) | JAK2LRRK2ALKCDK19AURKA | |
| SCHEMBL29816862 | 0.87 | CTSC (0.79) | JAK2LRRK2ALKCDK19AURKA | |
| SCHEMBL29816852 | 0.87 | CTSC (0.71) | JAK2LRRK2ALKCDK19AURKA | |
| SCHEMBL24842761 | 0.87 | CTSC (0.71) | JAK2LRRK2ALKCDK19AURKA | |
| SCHEMBL24842784 | 0.87 | CTSC (0.79) | JAK2LRRK2ALKCDK19AURKA | |
| SCHEMBL29816576 | 0.87 | CTSC (0.67) | JAK2LRRK2ALKCDK19AURKA | |
| SCHEMBL25658126 | 0.87 | CTSC (0.67) | JAK2LRRK2ALKCDK19AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022161274-A1 | PYRIMIDINE-2,4-DIAMINE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 安徽医科大学 | 2022-08-04 | — | — | WO | disclosed |