Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | PRKCG | P05129 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17933809 | 1.00 | PDE10A (0.39) | PDE10APDE5AAPPGAAPLAU | |
| SCHEMBL20119583 | 0.69 | TMIGD3 (0.43) | PDE10APDE5AAPPPLAUKDR | |
| SCHEMBL17926594 | 0.68 | ESR1 (0.43) | PDE10APDE5AAPPCCNE2CCNE1 | |
| SCHEMBL29833956 | 0.67 | PDE5A (0.48) | PDE10APDE5AAPPPLAUKDR | |
| SCHEMBL20119397 | 0.67 | PDE5A (0.48) | PDE10APDE5AAPPPLAUKDR | |
| SCHEMBL20119871 | 0.67 | PDE10A (0.52) | PDE10APDE5AAPPPLAUKDR | |
| SCHEMBL1308942 | 0.66 | CA12 (0.56) | PDE10AROCK2GRK2MEN1KMT2A | |
| SCHEMBL23498518 | 0.66 | PDE4A (0.64) | PDE5AAPPPDE4B | |
| SCHEMBL17933800 | 0.66 | SGK1 (0.51) | PDE10APDE5AAPPKDRFLT1 | |
| SCHEMBL20119883 | 0.66 | PDE5A (0.40) | PDE10APDE5AAPPPLAUKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3244891-B9 | COMPOUNDS FOR IMPROVING MRNA SPLICING | MASSACHUSETTS GEN HOSPITAL (US) | 2022-11-16 | — | — | EP | disclosed |
| EP-3244891-B1 | COMPOUNDS FOR IMPROVING MRNA SPLICING | MASSACHUSETTS GEN HOSPITAL (US) | 2022-07-20 | — | — | EP | disclosed |