Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE8B | O95263 | 1/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | IL1B | P01584 | 2/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29819929 | 1.00 | PDE8B (0.48) | PDE8BIRAK4ALDH1A1IL1BALOX5AP | |
| SCHEMBL27156891 | 1.00 | PDE8B (0.48) | PDE8BIRAK4ALDH1A1IL1BALOX5AP | |
| SCHEMBL29820209 | 0.97 | PDE8B (0.52) | PDE8BIRAK4ALDH1A1IL1BALOX5AP | |
| SCHEMBL29819803 | 0.94 | PDE8B (0.43) | PDE8BIRAK4ALDH1A1IL1BP2RX7 | |
| SCHEMBL27156880 | 0.86 | AURKA (0.37) | PDE8BIRAK4 | |
| SCHEMBL27156527 | 0.86 | AURKA (0.37) | PDE8BIRAK4 | |
| SCHEMBL27156349 | 0.85 | AURKA (0.35) | PDE8B | |
| SCHEMBL27156794 | 0.85 | AURKA (0.35) | PDE8B | |
| SCHEMBL27156358 | 0.85 | AURKA (0.35) | PDE8B | |
| SCHEMBL27156555 | 0.84 | AURKA (0.35) | PDE8BHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022197641-A1 | 1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-YL-AMINE DERIVATIVES AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) MODULATORS AND/OR INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER DISEASES | RAPT THERAPEUTICS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |