Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 13/20 | 0.56 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.52 |
| ▸ | BTK | Q06187 | 4/20 | 0.51 |
| ▸ | CCNC | P24863 | 1/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.48 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.48 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.48 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.48 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | HPGDS | O60760 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | IL2 | P60568 | 1/20 | 0.46 |
| ▸ | ITK | Q08881 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 2/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23117846 | 1.00 | CRBN (0.56) | CRBNDDB1BTKCCNCCDK8 | |
| SCHEMBL29822185 | 0.92 | CRBN (0.58) | CRBNDDB1BTKIRAK1IRAK4 | |
| SCHEMBL23117898 | 0.92 | CRBN (0.58) | CRBNDDB1BTKIRAK1IRAK4 | |
| SCHEMBL27098821 | 0.91 | CRBN (0.56) | CRBNDDB1BTKCCNCCDK8 | |
| SCHEMBL23134577 | 0.91 | CRBN (0.58) | CRBNDDB1BTKCCNCCDK8 | |
| SCHEMBL23133938 | 0.90 | CRBN (0.69) | CRBNDDB1BTKHPGDS | |
| SCHEMBL29821993 | 0.88 | CRBN (0.54) | CRBNDDB1BTKCCNCCDK8 | |
| SCHEMBL23172624 | 0.88 | CRBN (0.53) | CRBNDDB1BTKCCNCCDK8 | |
| SCHEMBL23117865 | 0.88 | CRBN (0.54) | CRBNDDB1BTKCCNCCDK8 | |
| SCHEMBL27099030 | 0.85 | CRBN (0.57) | CRBNDDB1BTKCCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4034114-A1 | NOVEL UREAS HAVING ANDROGEN RECEPTOR DEGRADATION ACTIVITY AND USES THEREOF | Accutar Biotechnology Inc. (US) | 2022-08-03 | — | — | EP | disclosed |