Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 14/20 | 0.51 |
| ▸ | IKZF2 | Q9UKS7 | 4/20 | 0.50 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.46 |
| ▸ | WIZ | O95785 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.43 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.43 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24675665 | 1.00 | CRBN (0.51) | CRBNIKZF2DDB1CSNK1A1WIZ | |
| SCHEMBL30942354 | 1.00 | CRBN (0.51) | CRBNIKZF2DDB1CSNK1A1WIZ | |
| SCHEMBL27302546 | 1.00 | CRBN (0.51) | CRBNIKZF2DDB1CSNK1A1WIZ | |
| SCHEMBL31027771 | 0.98 | IKZF2 (0.52) | CRBNIKZF2DDB1CSNK1A1WIZ | |
| SCHEMBL27424058 | 0.98 | IKZF2 (0.52) | CRBNIKZF2DDB1CSNK1A1WIZ | |
| SCHEMBL20231030 | 0.95 | CRBN (0.49) | CRBNIKZF2DDB1CSNK1A1WIZ | |
| SCHEMBL20235034 | 0.95 | CRBN (0.49) | CRBNIKZF2DDB1CSNK1A1WIZ | |
| SCHEMBL30942467 | 0.94 | IKZF2 (0.49) | CRBNIKZF2DDB1CSNK1A1WIZ | |
| SCHEMBL27302541 | 0.94 | IKZF2 (0.49) | CRBNIKZF2DDB1CSNK1A1WIZ | |
| SCHEMBL29648391 | 0.94 | IKZF2 (0.52) | CRBNIKZF2DDB1CSNK1A1WIZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4281445-A1 | DEGRADERS OF GRK2 AND USES THEREOF | Sonata Therapeutics, Inc. (US) | 2023-11-29 | — | — | EP | disclosed |
| WO-2022159688-A9 | DEGRADERS OF GRK2 AND USES THEREOF | SONATA THERAPEUTICS, INC. (US) | 2023-09-21 | — | — | WO | disclosed |
| WO-2023023537-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BRUTON'S TYROSINE KINASE | ENDOTARGET INC. (US) | 2023-02-23 | — | — | WO | disclosed |
| WO-2022159688-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2022-07-28 | — | — | WO | disclosed |