Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 14/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | TNKS | O95271 | 4/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GPR3 | P46089 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23537186 | 1.00 | PARP1 (0.53) | PARP1DYRK1ATNKSTNKS2KDM4E | |
| SCHEMBL29824193 | 0.89 | PARP1 (0.59) | PARP1DYRK1ATNKSTNKS2KDM4E | |
| SCHEMBL29824409 | 0.89 | PARP1 (0.64) | PARP1DYRK1ATNKSTNKS2KDM4E | |
| SCHEMBL23537328 | 0.89 | PARP1 (0.64) | PARP1DYRK1ATNKSTNKS2KDM4E | |
| SCHEMBL23537356 | 0.89 | PARP1 (0.59) | PARP1DYRK1ATNKSTNKS2KDM4E | |
| SCHEMBL30451928 | 0.81 | KDM4E (0.50) | PARP1DYRK1ATNKSTNKS2KDM4E | |
| SCHEMBL23537498 | 0.77 | PARP1 (0.45) | PARP1DYRK1ATNKSTNKS2KDM4E | |
| SCHEMBL29824598 | 0.77 | PARP1 (0.45) | PARP1DYRK1ATNKSTNKS2KDM4E | |
| SCHEMBL23537656 | 0.75 | PARP1 (0.44) | PARP1TNKSTNKS2KDM4EPARP15 | |
| SCHEMBL29824372 | 0.75 | PARP1 (0.44) | PARP1TNKSTNKS2KDM4EPARP15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076648-A1 | SUBSTITUTED BICYCLIC AND TRICYCLIC UREAS AND AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087486-A | Substituted bicyclic and tricyclic ureas and amides, analogs thereof, and methods of use thereof | 爱彼特生物制药公司 | 2022-09-20 | — | — | CN | disclosed |