Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 20/20 | 0.68 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.68 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.68 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.68 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.67 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.67 |
| ▸ | ERN2 | Q76MJ5 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27221138 | 1.00 | PIK3CB (0.68) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL910168 | 0.89 | PRKDC (0.78) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL24715027 | 0.85 | PIK3CB (0.73) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL24713615 | 0.85 | PIK3CB (0.78) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL24713823 | 0.85 | PIK3CB (0.73) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL24713557 | 0.83 | PIK3CB (0.69) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL1639382 | 0.83 | PIK3CB (0.83) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL24713631 | 0.83 | PIK3CB (0.72) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL24714319 | 0.82 | PIK3CB (0.71) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL24715030 | 0.82 | PIK3CB (0.68) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4284375-A1 | PHOSPHOINOSITIDE 3 KINASE BETA INHIBITORS AND COMPOSITIONS AND METHODS THEREOF | Geode Therapeutics Inc. (US) | 2023-12-06 | — | — | EP | disclosed |
| WO-2022164812-A1 | PHOSPHOINOSITIDE 3 KINASE BETA INHIBITORS AND COMPOSITIONS AND METHODS THEREOF | GEODE THERAPEUTICS INC. (US) | 2022-08-04 | — | — | WO | disclosed |