Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 20/20 | 0.71 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.71 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.71 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.62 |
| ▸ | PRKDC | P78527 | 1/20 | 0.61 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.60 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.60 |
| ▸ | ERN2 | Q76MJ5 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12668366 | 0.92 | PIK3CB (0.75) | PIK3CBPIK3CDPIK3CAPIK3CGKCNH2 | |
| SCHEMBL1871780 | 0.92 | PIK3CB (0.69) | PIK3CBPIK3CDPIK3CAPIK3CGKCNH2 | |
| Bromide SCHEMBL1868104 | 0.91 | PIK3CB (0.68) | PIK3CBPIK3CDPIK3CAPIK3CGKCNH2 | |
| SCHEMBL29826268 | 0.90 | PIK3CB (0.72) | PIK3CBPIK3CDPIK3CAPIK3CGKCNH2 | |
| SCHEMBL1868971 | 0.88 | PIK3CB (0.70) | PIK3CBPIK3CDPIK3CAPIK3CGKCNH2 | |
| SCHEMBL1866324 | 0.88 | PIK3CB (0.69) | PIK3CBPIK3CDPIK3CAPIK3CGKCNH2 | |
| SCHEMBL1637213 | 0.86 | PIK3CB (0.63) | PIK3CBPIK3CDPIK3CAPIK3CGKCNH2 | |
| SCHEMBL1639045 | 0.84 | PIK3CB (0.72) | PIK3CBPIK3CDPIK3CAPIK3CGKCNH2 | |
| SCHEMBL1638180 | 0.84 | PIK3CB (0.63) | PIK3CBPIK3CDPIK3CAPIK3CGKCNH2 | |
| SCHEMBL12667804 | 0.84 | PIK3CB (0.63) | PIK3CBPIK3CDPIK3CAPIK3CGKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117615763-A | Phosphoinositide 3 kinase beta inhibitor, composition and preparation method thereof | 健道生物医药有限公司 | 2024-02-27 | — | — | CN | disclosed |
| EP-4284375-A1 | PHOSPHOINOSITIDE 3 KINASE BETA INHIBITORS AND COMPOSITIONS AND METHODS THEREOF | Geode Therapeutics Inc. (US) | 2023-12-06 | — | — | EP | disclosed |
| WO-2022164812-A1 | PHOSPHOINOSITIDE 3 KINASE BETA INHIBITORS AND COMPOSITIONS AND METHODS THEREOF | GEODE THERAPEUTICS INC. (US) | 2022-08-04 | — | — | WO | disclosed |