Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23273849 | 1.00 | GRM5 (0.42) | GRM5SYKSMN1; SMN2MEN1LMNA | |
| SCHEMBL27240046 | 0.92 | MEN1 (0.40) | GRM5SMN1; SMN2MEN1LMNAKMT2A | |
| SCHEMBL23287990 | 0.90 | MEN1 (0.39) | GRM5SMN1; SMN2MEN1LMNAKMT2A | |
| SCHEMBL27240077 | 0.89 | SMO (0.41) | GRM5SMN1; SMN2MEN1LMNAKMT2A | |
| SCHEMBL27240040 | 0.86 | GRM5 (0.41) | GRM5SMN1; SMN2MEN1LMNAKMT2A | |
| SCHEMBL27240172 | 0.85 | GRM5 (0.39) | GRM5SYKSMN1; SMN2EGFRAURKB | |
| SCHEMBL23287969 | 0.85 | GRM5 (0.45) | GRM5SMN1; SMN2CSF1RPPARGNPC1 | |
| SCHEMBL27240085 | 0.85 | KDR (0.41) | GRM5SYKSMN1; SMN2PDGFRBRXFP1 | |
| SCHEMBL23273761 | 0.84 | CSF1R (0.42) | GRM5EGFRCSF1R | |
| SCHEMBL27240202 | 0.84 | GRM5 (0.41) | GRM5SMN1; SMN2MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4048399-A1 | INHIBITORS OF TREK (TWIK RELATED K+ CHANNELS) CHANNEL FUNCTION | ONO Pharmaceutical Co., Ltd. (JP) | 2022-08-31 | — | — | EP | disclosed |