Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14846086 | 0.86 | CYP1A2 (0.58) | KMT2AMEN1SMN1; SMN2L3MBTL1 | |
| SCHEMBL14679175 | 0.81 | MAPT (0.58) | KMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL6323754 | 0.79 | HTT (0.67) | PKMHTTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6327470 | 0.79 | MAPT (0.64) | KMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL6324681 | 0.78 | FFAR1 (0.75) | PKMHTTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL29496321 | 0.77 | MAPT (0.47) | KMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL12580581 | 0.77 | MCL1 (0.59) | PKMHTTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL14736541 | 0.76 | MAPT (0.46) | KMT2AMEN1SMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL22649322 | 0.76 | PPARD (0.53) | SMN1; SMN2MAPT | |
| SCHEMBL29463559 | 0.76 | PPARD (0.53) | SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308575-A1 | MACROCYCLES AS CFTR MODULATORS | Idorsia Pharmaceuticals Ltd (CH) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022194399-A1 | MACROCYCLES AS CFTR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2022-09-22 | — | — | WO | disclosed |