Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9959180 | 1.00 | BACE1 (0.46) | BACE1APP | |
| SCHEMBL9958432 | 0.86 | BACE1 (0.44) | BACE1APP | |
| SCHEMBL30392 | 0.86 | BACE1 (0.44) | BACE1APP | |
| SCHEMBL9958466 | 0.79 | BACE1 (0.40) | BACE1APP | |
| SCHEMBL31076 | 0.79 | BACE1 (0.40) | BACE1APP | |
| SCHEMBL19567109 | 0.79 | BACE1 (0.48) | BACE1APP | |
| SCHEMBL12317891 | 0.79 | BACE1 (0.48) | BACE1APP | |
| SCHEMBL30562 | 0.78 | BACE1 (0.49) | BACE1 | |
| SCHEMBL19566697 | 0.77 | BACE1 (0.55) | BACE1APP | |
| SCHEMBL1466510 | 0.77 | BACE1 (0.50) | BACE1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780321-A1 | MONO-FLUORO BETA-SECRETASE INHIBITORS | Astrazeneca AB (SE) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013054108-A1 | MONO-FLUORO BETA-SECRETASE INHIBITORS | ASTRAZENECA AB (SE) | 2013-04-18 | — | — | WO | disclosed |
| EP-2406240-A2 | INHIBITORS OF BETA-SECRETASE | Vitae Pharmaceuticals, Inc. (US) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010105179-A2 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS, INC. (US) | 2010-09-16 | — | — | WO | disclosed |