Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.75 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | DHODH | Q02127 | 5/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL290826 | 1.00 | PDE5A (0.75) | PDE5AMAPTKDM4EDHODHNPSR1 | |
| SCHEMBL29831847 | 0.92 | PDE5A (0.75) | PDE5AMAPTKDM4EDHODHNPSR1 | |
| SCHEMBL291639 | 0.92 | PDE5A (0.75) | PDE5AMAPTKDM4EDHODHNPSR1 | |
| SCHEMBL29832221 | 0.92 | PDE5A (0.78) | PDE5AMAPTKDM4EDHODHNPSR1 | |
| SCHEMBL290493 | 0.92 | PDE5A (0.78) | PDE5AMAPTKDM4EDHODHNPSR1 | |
| SCHEMBL6068299 | 0.87 | PDE5A (0.86) | PDE5AMAPTKDM4EDHODHNPSR1 | |
| SCHEMBL290844 | 0.87 | PDE5A (1.00) | PDE5AMAPTKDM4EDHODHNPSR1 | |
| SCHEMBL29408529 | 0.85 | PDE5A (0.69) | PDE5AMAPTKDM4EDHODHNPSR1 | |
| SCHEMBL290309 | 0.85 | PDE5A (0.69) | PDE5AMAPTKDM4EDHODHNPSR1 | |
| SCHEMBL6068122 | 0.84 | PDE5A (0.74) | PDE5AMAPTKDM4EDHODHNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115192711-A | Use of PDE7 inhibitors for the treatment of movement disorders | 奥默罗斯公司 | 2022-10-18 | — | — | CN | disclosed |
| CN-114984229-A | Treatment of addiction and impulse control disorders using PDE7 inhibitors | 奥默罗斯公司 | 2022-09-02 | — | — | CN | disclosed |