Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 20/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17785431 | 1.00 | KLKB1 (0.78) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL17785333 | 0.93 | KLKB1 (0.77) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL17785328 | 0.88 | KLKB1 (1.00) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL29835941 | 0.87 | KLKB1 (0.84) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL17785313 | 0.87 | KLKB1 (0.84) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL17785425 | 0.84 | KLKB1 (1.00) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL24176220 | 0.84 | KLKB1 (0.83) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL17785320 | 0.82 | KLKB1 (0.68) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL17785370 | 0.81 | KLKB1 (1.00) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL17785324 | 0.80 | KLKB1 (1.00) | KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4039681-A1 | N-((HET)ARYLMETHYL)-HETEROARYL-CARBOXAMIDES COMPOUNDS AS PLASMA KALLIKREIN INHIBITORS | Kalvista Pharmaceuticals Limited (GB) | 2022-08-10 | — | — | EP | disclosed |