Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 7/20 | 0.57 |
| ▸ | RHOA | P61586 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL420156 | 1.00 | SERPINE1 (0.57) | SERPINE1RHOAKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL415948 | 0.92 | RHOA (0.47) | SERPINE1RHOAKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL419505 | 0.86 | SERPINE1 (0.58) | SERPINE1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL419504 | 0.86 | SERPINE1 (0.58) | SERPINE1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL419591 | 0.86 | SERPINE1 (0.62) | SERPINE1RHOAALDH1A1 | |
| SCHEMBL416973 | 0.85 | SERPINE1 (0.61) | SERPINE1RHOAALDH1A1 | |
| SCHEMBL418577 | 0.79 | SERPINE1 (0.73) | SERPINE1KDM4EHSD17B10ALDH1A1POLB | |
| SCHEMBL416972 | 0.78 | RHOA (0.56) | SERPINE1RHOAALDH1A1 | |
| SCHEMBL417046 | 0.78 | SERPINE1 (0.47) | SERPINE1ALDH1A1 | |
| SCHEMBL417045 | 0.78 | SERPINE1 (0.47) | SERPINE1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4039276-A1 | INHIBITOR AGAINST EXPRESSION OF IMMUNE CHECKPOINT MOLECULE | Renascience Inc. (JP) | 2022-08-10 | — | — | EP | disclosed |