Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 7/20 | 0.81 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.59 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | KDM1A | O60341 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | ITK | Q08881 | 1/20 | 0.50 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.48 |
| ▸ | KMO | O15229 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL422315 | 1.00 | SERPINE1 (0.81) | SERPINE1DEGS1ACMSDHDAC8HDAC6 | |
| SCHEMBL419193 | 0.90 | SERPINE1 (1.00) | SERPINE1DEGS1HDAC8HDAC6HDAC3 | |
| SCHEMBL416727 | 0.87 | SERPINE1 (0.70) | SERPINE1DEGS1ACMSDHDAC8HDAC6 | |
| SCHEMBL419124 | 0.84 | SERPINE1 (0.66) | SERPINE1DEGS1HDAC8HDAC6HDAC3 | |
| SCHEMBL29838650 | 0.84 | SERPINE1 (0.66) | SERPINE1DEGS1ACMSDHDAC8HDAC6 | |
| SCHEMBL416992 | 0.84 | SERPINE1 (0.66) | SERPINE1DEGS1ACMSDHDAC8HDAC6 | |
| SCHEMBL27574066 | 0.83 | SERPINE1 (0.65) | SERPINE1DEGS1ACMSDHDAC8HDAC6 | |
| SCHEMBL418963 | 0.82 | SERPINE1 (0.64) | SERPINE1DEGS1ACMSDHDAC8HDAC6 | |
| SCHEMBL2272370 | 0.81 | SERPINE1 (0.59) | SERPINE1DEGS1ACMSDHDAC8HDAC6 | |
| SCHEMBL419189 | 0.79 | SERPINE1 (1.00) | SERPINE1KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4039276-A1 | INHIBITOR AGAINST EXPRESSION OF IMMUNE CHECKPOINT MOLECULE | Renascience Inc. (JP) | 2022-08-10 | — | — | EP | disclosed |