Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.86 |
| ▸ | BTK | Q06187 | 9/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24735215 | 1.00 | EGFR (0.86) | EGFRBTK | |
| SCHEMBL24734993 | 0.95 | EGFR (0.83) | EGFRBTK | |
| SCHEMBL29841271 | 0.95 | EGFR (0.83) | EGFRBTK | |
| SCHEMBL24734999 | 0.95 | EGFR (0.83) | EGFRBTK | |
| SCHEMBL17339313 | 0.94 | EGFR (0.85) | EGFRBTK | |
| SCHEMBL24734952 | 0.93 | EGFR (0.88) | EGFRBTK | |
| SCHEMBL29841448 | 0.93 | EGFR (0.88) | EGFRBTK | |
| SCHEMBL18665608 | 0.92 | EGFR (1.00) | EGFRBTK | |
| SCHEMBL31611556 | 0.91 | EGFR (0.89) | EGFRBTK | |
| SCHEMBL25378572 | 0.91 | EGFR (0.89) | EGFRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4501327-A2 | SUBSTITUTED PYRROLOPYRIMIDINE AND PYRAZOLOPYRIMIDINE AS BRUTON S TYROSINEKINASE (BTK) DEGRADERS | Accutar Biotechnology Inc. (US) | 2025-02-05 | — | — | EP | disclosed |
| EP-4039688-B1 | SUBSTITUTED PYRROLOPYRIMIDINE AND PYRAZOLOPYRIMIDINE AS BRUTON'S TYROSINE KINASE (BTK) DEGRADERS | ACCUTAR BIOTECHNOLOGY INC (US) | 2024-10-09 | — | — | EP | disclosed |
| CN-117042769-A | Substituted pyrrolopyrimidines and pyrazolopyrimidines as Bruton's Tyrosine Kinase (BTK) degrading agents | 冰洲石生物科技公司 | 2023-11-10 | — | — | CN | disclosed |
| WO-2022169798-A2 | SUBSTITUTED PYRROLOPYRIMIDINE AND PYRAZOLOPYRIMIDINE AS BRUTON'S TYROSINE KINASE (BTK) DEGRADERS | ACCUTAR BIOTECHNOLOGY, INC. (US) | 2022-08-11 | — | — | WO | disclosed |
| EP-4039688-A2 | SUBSTITUTED PYRROLOPYRIMIDINE AND PYRAZOLOPYRIMIDINE AS BRUTON'S TYROSINE KINASE (BTK) DEGRADERS | Accutar Biotechnology Inc. (US) | 2022-08-10 | — | — | EP | disclosed |