Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.51 |
| ▸ | KDR | P35968 | 13/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23166490 | 1.00 | BRAF (0.51) | BRAFKDRRAF1 | |
| SCHEMBL23166538 | 0.88 | BRAF (0.56) | BRAFKDRRAF1 | |
| SCHEMBL29845507 | 0.88 | BRAF (0.56) | BRAFKDRRAF1 | |
| SCHEMBL23205579 | 0.86 | ABL1 (0.52) | BRAFKDRRAF1 | |
| SCHEMBL29845647 | 0.84 | BRAF (0.43) | BRAFKDRRAF1 | |
| SCHEMBL23166690 | 0.84 | BRAF (0.43) | BRAFKDRRAF1 | |
| SCHEMBL30313590 | 0.83 | BRAF (0.57) | BRAFKDRRAF1 | |
| SCHEMBL24007226 | 0.83 | BRAF (0.57) | BRAFKDRRAF1 | |
| SCHEMBL23167163 | 0.82 | BRAF (0.51) | BRAFKDR | |
| SCHEMBL29845577 | 0.82 | BRAF (0.51) | BRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4041236-A1 | TRICYCLIC KINASE INHIBITORS AND USES THEREOF | Dana-Farber Cancer Institute, Inc. (US) | 2022-08-17 | — | — | EP | disclosed |