Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 12/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.35 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.32 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.32 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23753819 | 1.00 | PIK3CG (0.37) | PIK3CGPIK3CDPAK4JAK1PIK3CA | |
| SCHEMBL23753752 | 0.89 | PIK3CG (0.36) | PIK3CGPIK3CDPAK4JAK1PIK3CA | |
| SCHEMBL29846800 | 0.89 | PIK3CG (0.36) | PIK3CGPIK3CDPAK4JAK1PIK3CA | |
| SCHEMBL29847002 | 0.84 | PIK3CG (0.37) | PIK3CGPIK3CDPAK4JAK1PIK3CA | |
| SCHEMBL23753835 | 0.84 | PIK3CG (0.37) | PIK3CGPIK3CDPAK4JAK1PIK3CA | |
| SCHEMBL23753946 | 0.83 | PIK3CG (0.37) | PIK3CGPIK3CDPAK4JAK1PIK3CA | |
| SCHEMBL29846901 | 0.83 | PIK3CG (0.37) | PIK3CGPIK3CDPAK4JAK1PIK3CA | |
| SCHEMBL23753863 | 0.83 | PIK3CG (0.37) | PIK3CGPIK3CDPAK4JAK1PIK3CA | |
| SCHEMBL23753806 | 0.83 | PIK3CG (0.37) | PIK3CGPIK3CDPAK4JAK1PIK3CA | |
| SCHEMBL29846978 | 0.83 | PIK3CG (0.37) | PIK3CGPIK3CDPAK4JAK1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115135648-B | Dihydronaphthyridones, preparation method and medical application thereof | 劲方医药科技(上海)有限公司 | 2024-02-09 | — | — | CN | disclosed |
| CN-115135648-A | Dihydronaphthyridinone compounds, preparation method and medical application thereof | 劲方医药科技(上海)有限公司 | 2022-09-30 | — | — | CN | disclosed |