Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | WEE1 | P30291 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16514857 | 1.00 | ACVR1 (0.42) | ACVR1EGFRMYLK4CLK4STK17A | |
| SCHEMBL16823073 | 0.92 | CDK4 (0.43) | ACVR1EGFRMYLK4CLK4STK17A | |
| SCHEMBL16514757 | 0.91 | MAPK10 (0.47) | EGFRSRCJAK2BRD4CSF1R | |
| SCHEMBL16514044 | 0.90 | JAK2 (0.51) | ACVR1EGFRJAK2BRD4CDK4 | |
| SCHEMBL29847745 | 0.90 | JAK2 (0.51) | ACVR1EGFRJAK2BRD4CDK4 | |
| SCHEMBL16514537 | 0.89 | MYLK4 (0.44) | ACVR1EGFRMYLK4CLK4STK17A | |
| SCHEMBL16514675 | 0.89 | ACVR1 (0.45) | ACVR1EGFRMYLK4CLK4STK17A | |
| SCHEMBL31679045 | 0.89 | ACVR1 (0.45) | ACVR1EGFRMYLK4CLK4STK17A | |
| SCHEMBL29847614 | 0.89 | MYLK4 (0.44) | ACVR1EGFRMYLK4CLK4STK17A | |
| SCHEMBL16513501 | 0.88 | CDK4 (0.40) | ACVR1EGFRMYLK4CLK4STK17A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109851617-B | Chemical entities, compositions, and methods | 润新生物公司 | 2022-08-16 | — | — | CN | disclosed |