Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | PLEC | Q15149 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18969570 | 1.00 | KDM4E (0.45) | KDM4EUSP2GAAALDH1A1MAPT | |
| SCHEMBL10687263 | 0.89 | MAPT (0.51) | KDM4EGAAALDH1A1MAPTATM | |
| SCHEMBL29850635 | 0.88 | HTT (0.51) | KDM4EGAAALDH1A1MAPTHPGD | |
| SCHEMBL18940654 | 0.88 | HTT (0.51) | KDM4EGAAALDH1A1MAPTHPGD | |
| SCHEMBL23971179 | 0.84 | PTGER4 (0.49) | KDM4EUSP2GAAALDH1A1MAPT | |
| SCHEMBL31571829 | 0.84 | KDM4E (0.42) | KDM4EUSP2GAAALDH1A1MAPT | |
| SCHEMBL18940647 | 0.83 | KDM4E (0.49) | KDM4EUSP2GAAALDH1A1MAPT | |
| SCHEMBL19437460 | 0.82 | KDM4E (0.43) | KDM4EUSP2GAAALDH1A1MAPT | |
| SCHEMBL20886126 | 0.82 | PDE4A (0.47) | KDM4EGAAALDH1A1MAPTHPGD | |
| SCHEMBL23971183 | 0.82 | KDM4E (0.44) | KDM4EUSP2GAAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109069869-B | Bicyclic PAD4 inhibitors | 帕德罗科治疗公司 | 2022-09-13 | — | — | CN | disclosed |