Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24312244 | 0.78 | MAPT (0.41) | MAPTTOP2ANAMPTCYP19A1QRFPR | |
| SCHEMBL17558908 | 0.76 | MAPT (0.42) | MAPTKCNH2TOP2ANAMPTCYP19A1 | |
| SCHEMBL10151406 | 0.76 | MAPT (0.47) | MAPTKCNH2PDE10ATOP2ANAMPT | |
| SCHEMBL19559026 | 0.75 | MAPT (0.41) | MAPTKCNH2TOP2ANAMPTCYP19A1 | |
| SCHEMBL22502909 | 0.74 | MAPT (0.46) | MAPTKCNH2TOP2ACYP19A1HASPIN | |
| SCHEMBL19233685 | 0.74 | MAPT (0.46) | MAPTKCNH2TOP2ACYP19A1HASPIN | |
| SCHEMBL30771606 | 0.74 | MAPT (0.41) | MAPTNAMPTCYP19A1 | |
| SCHEMBL1882418 | 0.73 | KMT2A (0.50) | — | |
| SCHEMBL22792465 | 0.71 | MAPT (0.44) | MAPTKCNH2TOP2ANAMPTCYP19A1 | |
| SCHEMBL14327804 | 0.71 | MAPT (0.44) | MAPTKCNH2TOP2ANAMPTCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022169974-A1 | INHIBITORS OF URAT1 AND PHARMACEUTICAL USES THEREOF | NEXYS THERAPEUTICS, INC. (US) | 2022-08-11 | — | — | WO | disclosed |