Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 4/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14327804 | 1.00 | MAPT (0.44) | MAPTATMKCNH2AOC3TOP2A | |
| SCHEMBL23478504 | 0.86 | ATM (0.41) | MAPTATMTOP2AHASPINROCK2 | |
| SCHEMBL22016213 | 0.77 | MAPT (0.40) | MAPTKCNH2TOP2ANAMPTCYP19A1 | |
| SCHEMBL10151406 | 0.76 | MAPT (0.47) | MAPTATMKCNH2AOC3TOP2A | |
| SCHEMBL19233685 | 0.74 | MAPT (0.46) | MAPTKCNH2TOP2ACYP19A1HASPIN | |
| SCHEMBL22502909 | 0.74 | MAPT (0.46) | MAPTKCNH2TOP2ACYP19A1HASPIN | |
| SCHEMBL9887744 | 0.73 | KMT2A (0.55) | MAPT | |
| SCHEMBL1569013 | 0.72 | MCL1 (0.60) | MAPTNAMPTHASPIN | |
| SCHEMBL30220531 | 0.72 | MCL1 (0.60) | MAPTNAMPTHASPIN | |
| SCHEMBL26828095 | 0.72 | KMT2A (0.64) | MAPTATMKCNH2AOC3TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022169974-A1 | INHIBITORS OF URAT1 AND PHARMACEUTICAL USES THEREOF | NEXYS THERAPEUTICS, INC. (US) | 2022-08-11 | — | — | WO | disclosed |