Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26916894 | 1.00 | LRRK2 (0.42) | LRRK2CGASMAPTHTTLMNA | |
| SCHEMBL29857938 | 1.00 | LRRK2 (0.42) | LRRK2CGASMAPTHTTLMNA | |
| SCHEMBL26917000 | 1.00 | LRRK2 (0.42) | LRRK2CGASMAPTHTTLMNA | |
| SCHEMBL26916891 | 1.00 | LRRK2 (0.42) | LRRK2CGASMAPTHTTLMNA | |
| SCHEMBL26916901 | 0.88 | LRRK2 (0.40) | LRRK2MAPTHTTLMNAKMT2A | |
| SCHEMBL26916906 | 0.88 | LRRK2 (0.40) | LRRK2MAPTHTTLMNAKMT2A | |
| SCHEMBL29857833 | 0.87 | LRRK2 (0.35) | LRRK2MAPTHTTLMNAKMT2A | |
| SCHEMBL26917105 | 0.87 | LRRK2 (0.35) | LRRK2MAPTHTTLMNAKMT2A | |
| SCHEMBL29857862 | 0.87 | LRRK2 (0.35) | LRRK2MAPTHTTLMNAKMT2A | |
| SCHEMBL26916824 | 0.87 | LRRK2 (0.35) | LRRK2MAPTHTTLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4288437-A1 | MAP4K1 INHIBITORS | Bayer Aktiengesellschaft (DE) | 2023-12-13 | — | — | EP | disclosed |
| WO-2022167627-A1 | MAP4K1 INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2022-08-11 | — | — | WO | disclosed |