Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.49 |
| ▸ | FYN | P06241 | 6/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | LTK | P29376 | 1/20 | 0.46 |
| ▸ | GRK5 | P34947 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12516853 | 1.00 | ADORA1 (0.49) | ADORA1FYNMAP4K4CHEK1ABL1 | |
| SCHEMBL19721378 | 0.85 | KMT2A (0.47) | FYNMAP4K4KMT2ARAB9ANPC1 | |
| SCHEMBL20288103 | 0.85 | CYP2A6 (0.57) | ADORA1FYNMAP4K4CHEK1ABL1 | |
| SCHEMBL13968119 | 0.81 | MAP4K4 (0.54) | FYNMAP4K4LRRK2KMT2ARAB9A | |
| SCHEMBL29857960 | 0.81 | MAP4K4 (0.54) | FYNMAP4K4LRRK2KMT2ARAB9A | |
| SCHEMBL15359055 | 0.81 | USP7 (0.60) | FYNMAP4K4FGFR1KDRFLT3 | |
| SCHEMBL29857829 | 0.81 | CHEK2 (0.53) | FYNMAP4K4KMT2AHTTMEN1 | |
| SCHEMBL2226848 | 0.81 | FYN (0.54) | ADORA1FYNMAP4K4PDGFRBPIM1 | |
| SCHEMBL26917180 | 0.81 | CHEK2 (0.53) | FYNMAP4K4KMT2AHTTMEN1 | |
| SCHEMBL4582434 | 0.81 | ADORA1 (0.49) | ADORA1FYNMAP4K4CHEK1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4288437-A1 | MAP4K1 INHIBITORS | Bayer Aktiengesellschaft (DE) | 2023-12-13 | — | — | EP | disclosed |
| WO-2022167627-A1 | MAP4K1 INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2022-08-11 | — | — | WO | disclosed |