Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 2/20 | 0.33 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 2/20 | 0.31 |
| ▸ | NOS2 | P35228 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25573075 | 0.82 | TYK2 (0.32) | CSNK1DNUAK1ROCK2MAP4K4LCK | |
| SCHEMBL29866374 | 0.82 | TYK2 (0.32) | CSNK1DNUAK1ROCK2MAP4K4LCK | |
| SCHEMBL29865879 | 0.81 | CSNK1D (0.36) | CSNK1DNUAK1ROCK2MAP4K4LCK | |
| SCHEMBL29865894 | 0.80 | PDE10A (0.32) | — | |
| SCHEMBL30663579 | 0.79 | CHRM2 (0.36) | MAP4K4NOS3NOS2 | |
| SCHEMBL29866438 | 0.77 | TYK2 (0.44) | CSNK1DNUAK1ROCK2MAP4K4LCK | |
| SCHEMBL25573092 | 0.77 | TYK2 (0.44) | CSNK1DNUAK1ROCK2MAP4K4LCK | |
| SCHEMBL29866286 | 0.77 | TYK2 (0.40) | CSNK1D | |
| SCHEMBL30696887 | 0.76 | TYK2 (0.33) | — | |
| SCHEMBL26677529 | 0.76 | TYK2 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4294806-A1 | TYK2 INHIBITORS AND USES THEREOF | Sudo Biosciences Limited (GB) | 2023-12-27 | — | — | EP | disclosed |
| CN-117120440-A | TYK2 inhibitor and application thereof | 苏多生物科学有限公司 | 2023-11-24 | — | — | CN | disclosed |
| WO-2022175746-A1 | TYK2 INHIBITORS AND USES THEREOF | SUDO BIOSCIENCES LIMITED (GB) | 2022-08-25 | — | — | WO | disclosed |