Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Vidofludimus. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH known ✓ | Q02127 | 20/20 | 0.76 |
| ▸ | NR4A2 | P43354 | 11/20 | 0.76 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.65 |
| ▸ | JMJD7 | P0C870 | 1/20 | 0.65 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.65 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Vidofludimus SCHEMBL29869156 | 0.86 | DHODH (1.00) | DHODHNR4A2NR4A1JMJD7NR4A3 | |
| SCHEMBL29868738 | 0.84 | DHODH (0.71) | DHODHNR4A2NR4A1JMJD7NR4A3 | |
| Vidofludimus SCHEMBL29868416 | 0.83 | DHODH (0.85) | DHODHNR4A2NR4A1JMJD7NR4A3 | |
| SCHEMBL3925167 | 0.80 | DHODH (1.00) | DHODHNR4A2NR4A1JMJD7NR4A3 | |
| Vidofludimus SCHEMBL247888 | 0.79 | DHODH (1.00) | DHODHNR4A2NR4A1JMJD7NR4A3 | |
| Vidofludimus SCHEMBL29352865 | 0.79 | DHODH (1.00) | DHODHNR4A2NR4A1JMJD7NR4A3 | |
| Vidofludimus SCHEMBL28974266 | 0.78 | DHODH (0.98) | DHODHNR4A2NR4A1JMJD7NR4A3 | |
| SCHEMBL29868489 | 0.78 | DHODH (0.62) | DHODHNR4A2NR4A1JMJD7NR4A3 | |
| SCHEMBL18118644 | 0.78 | DHODH (0.83) | DHODHNR4A2NR4A1JMJD7NR4A3 | |
| SCHEMBL3918628 | 0.77 | DHODH (0.78) | DHODHNR4A2NR4A1JMJD7NR4A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4320100-A1 | DEUTERATED DHODH INHIBITORS | Immunic AG (DE) | 2024-02-14 | — | — | EP | disclosed |
| WO-2022214691-A1 | DEUTERATED DHODH INHIBITORS | IMMUNIC AG (DE) | 2022-10-13 | — | — | WO | disclosed |