Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 16/20 | 0.88 |
| ▸ | PLK3 | Q9H4B4 | 11/20 | 0.88 |
| ▸ | NEK2 | P51955 | 7/20 | 0.74 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.74 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.74 |
| ▸ | PIM1 | P11309 | 3/20 | 0.74 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.74 |
| ▸ | KDR | P35968 | 2/20 | 0.74 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.74 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.56 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.56 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.56 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.56 |
| ▸ | STK10 | O94804 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.56 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.56 |
| ▸ | GRK4 | P32298 | 1/20 | 0.56 |
| ▸ | TIE1 | P35590 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551432 | 0.94 | PLK1 (1.00) | PLK1PLK3NEK2PIK3CDPDGFRB | |
| SCHEMBL2982249 | 0.94 | PLK1 (1.00) | PLK1PLK3NEK2PIK3CDPDGFRB | |
| SCHEMBL2987660 | 0.93 | PLK1 (0.86) | PLK1PLK3NEK2PIK3CDPDGFRB | |
| SCHEMBL2987851 | 0.92 | PLK1 (0.88) | PLK1PLK3NEK2PIK3CDPDGFRB | |
| SCHEMBL14029522 | 0.91 | PLK1 (0.95) | PLK1PLK3NEK2PIK3CDPDGFRB | |
| SCHEMBL14029523 | 0.91 | PLK1 (0.95) | PLK1PLK3NEK2PIK3CDPDGFRB | |
| Trifluoroacetic Acid SCHEMBL4403025 | 0.90 | PLK1 (0.90) | PLK1PLK3NEK2PIK3CDPDGFRB | |
| Trifluoroacetic Acid SCHEMBL5006530 | 0.90 | PLK1 (0.90) | PLK1PLK3NEK2PIK3CDPDGFRB | |
| SCHEMBL2977625 | 0.89 | PLK1 (0.73) | PLK1PLK3NEK2PIK3CDPDGFRB | |
| SCHEMBL2977519 | 0.85 | PLK1 (1.00) | PLK1PLK3NEK2PIK3CDPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786127-B2 | Benzimidazole thiophene compounds | Glaxo SmithKline LLC (US) | 2010-08-31 | — | — | US | disclosed |
| US-7595330-B2 | Benzimidazole thiophene compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2009-09-29 | — | — | US | disclosed |
| US-20080249301-A1 | Regioselective Process for Preparing Benzimidazole Thiophenes | SMITHKLINE BEECHAM CORPORATION | 2008-10-09 | — | — | US | disclosed |
| US-20080214567-A1 | Benzimidazole Thiophene Compounds | GLAXOSMITHKLINE LLC | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214567-A1 | Benzimidazole Thiophene Compounds | ABCB1, ABCG2, CYP3A5 | PLK1 344/4885PLK3 934/4885NEK2 2296/4885 |
| US-20080249301-A1 | Regioselective Process for Preparing Benzimidazole Thiophenes | CYP3A4, CYP2C19, CYP2B6 | PLK1 1718/4885PLK3 2097/4885NEK2 1915/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.