Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 5/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.35 |
| ▸ | CDK9 | P50750 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29619699 | 0.97 | CHRM4 (0.50) | CHRM4CHRM1CHRM2CHRM5GPR119 | |
| SCHEMBL29903276 | 0.94 | CHRM4 (0.53) | CHRM4CHRM1CHRM2CHRM5GPR119 | |
| SCHEMBL23213516 | 0.94 | CHRM4 (0.53) | CHRM4CHRM1CHRM2CHRM5GPR119 | |
| SCHEMBL29871426 | 0.90 | CHRM4 (0.49) | CHRM4CHRM1CHRM2CHRM5GPR119 | |
| SCHEMBL23213177 | 0.89 | CHRM4 (0.52) | CHRM4CHRM1CHRM2CHRM5CCNT1 | |
| SCHEMBL23213464 | 0.83 | CHRM4 (0.53) | CHRM4CHRM1CHRM2CHRM5CDK9 | |
| SCHEMBL27210394 | 0.83 | CHRM4 (0.53) | CHRM4CHRM1CHRM2CHRM5CDK9 | |
| SCHEMBL29619692 | 0.82 | CHRM4 (0.54) | CHRM4CHRM1CHRM2CHRM5GPR119 | |
| SCHEMBL23213017 | 0.82 | CHRM4 (0.56) | CHRM4CHRM1CHRM2CHRM5CCNT1 | |
| SCHEMBL23213412 | 0.80 | CHRM4 (0.58) | CHRM4CHRM1CHRM2CHRM5GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4041737-A1 | 5-OXA-2-AZASPIRO[3.4]OCTANE DERIVATIVES AS M4 AGONISTS | Novartis AG (CH) | 2022-08-17 | — | — | EP | disclosed |