Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.74 |
| ▸ | JAK3 | P52333 | 12/20 | 0.74 |
| ▸ | LCK | P06239 | 10/20 | 0.74 |
| ▸ | EGFR | P00533 | 4/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18283475 | 1.00 | BTK (0.74) | BTKJAK3LCKEGFR | |
| SCHEMBL18283479 | 1.00 | BTK (0.74) | BTKJAK3LCKEGFR | |
| SCHEMBL18284013 | 1.00 | BTK (0.74) | BTKJAK3LCKEGFR | |
| SCHEMBL18296088 | 0.94 | BTK (0.69) | BTKJAK3LCKEGFR | |
| SCHEMBL22346051 | 0.88 | BTK (0.84) | BTKJAK3LCKEGFR | |
| SCHEMBL22346050 | 0.88 | BTK (0.84) | BTKJAK3LCKEGFR | |
| SCHEMBL18296268 | 0.88 | BTK (0.71) | BTKJAK3LCKEGFR | |
| SCHEMBL23080808 | 0.88 | BTK (0.70) | BTKJAK3LCKEGFR | |
| SCHEMBL20540650 | 0.88 | BTK (0.81) | BTKJAK3LCKEGFR | |
| SCHEMBL18283934 | 0.88 | BTK (0.81) | BTKJAK3LCKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4069237-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY | Nurix Therapeutics, Inc. (US) | 2022-10-12 | — | — | EP | disclosed |
| CN-115003304-A | Bifunctional compounds for the degradation of BTK via the ubiquitin proteasome pathway | 纽力克斯治疗公司 | 2022-09-02 | — | — | CN | disclosed |