Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 14/20 | 0.78 |
| ▸ | CCNB2 | O95067 | 10/20 | 0.71 |
| ▸ | CDK1 | P06493 | 10/20 | 0.71 |
| ▸ | CCNB1 | P14635 | 10/20 | 0.71 |
| ▸ | CCNB3 | Q8WWL7 | 10/20 | 0.71 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.61 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.61 |
| ▸ | CDK2 | P24941 | 2/20 | 0.61 |
| ▸ | CDK9 | P50750 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13007942 | 0.88 | RET (1.00) | RETCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL13007941 | 0.87 | RET (1.00) | RETCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL3771028 | 0.87 | RET (0.77) | RETCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL13007940 | 0.87 | RET (1.00) | RETCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL13007936 | 0.86 | RET (1.00) | RETCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL13007924 | 0.83 | CDK1 (1.00) | RETCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL3769950 | 0.83 | CDK1 (0.73) | RETCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL3778518 | 0.82 | RET (1.00) | RETCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL13008009 | 0.82 | RET (0.69) | RETCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL13007931 | 0.82 | RET (1.00) | RETCCNB2CDK1CCNB1CCNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173923-A1 | 4 (PYRROLOPYRIDINYL)PYRIMIDINYL-2-AMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-07-08 | — | — | US | claimed |
| US-20100173923-A1 | 4 (PYRROLOPYRIDINYL)PYRIMIDINYL-2-AMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173923-A1 | 4 (PYRROLOPYRIDINYL)PYRIMIDINYL-2-AMINE DERIVATIVES | MKI67, CDK4, CCNT1 | RET 418/4885CCNB2 24/4885CDK1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.