SCHEMBL29874222

SCHEMBL29874222

CNC(=O)COc1cc2cc(Nc3nc(N4CCC[C@H](CO)C4)ncc3Cl)ccc2n(C)c1=O

nearest known ligand 0.74

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ BCL6 P41182 20/20 0.74
▸ MELK Q14680 1/20 0.74
▸ NCOR2 Q9Y618 5/20 0.73
▸ CHRM4 P08173 1/20 0.55
▸ BCL6B Q8N143 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23250134 1.00 BCL6 (0.74) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL23250133 1.00 BCL6 (0.74) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL23267841 0.94 BCL6 (0.73) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL20284584 0.92 BCL6 (0.70) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL23267126 0.91 BCL6 (0.83) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL22421725 0.91 BCL6 (0.76) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL21787647 0.91 BCL6 (0.83) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL20284056 0.91 BCL6 (0.83) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL20267383 0.90 BCL6 (0.74) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL21787553 0.90 BCL6 (0.68) BCL6MELKNCOR2CHRM4BCL6B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4045496-A1 BIFUNCTIONAL MOLECULES CONTAINING AN E3 UBIQUITINE LIGASE BINDING MOIETY LINKED TO A BCL6 TARGETING MOIETY Arvinas Operations, Inc. (US) 2022-08-24 — — EP disclosed
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