Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 1.00 |
| ▸ | SNCA | P37840 | 1/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.46 |
| ▸ | IKZF2 | Q9UKS7 | 7/20 | 0.40 |
| ▸ | WIZ | O95785 | 2/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23364377 | 1.00 | MAPT (1.00) | MAPTSNCACRBNIKZF2WIZ | |
| SCHEMBL23386223 | 1.00 | MAPT (1.00) | MAPTSNCACRBNIKZF2WIZ | |
| SCHEMBL29453220 | 1.00 | MAPT (1.00) | MAPTSNCACRBNIKZF2WIZ | |
| SCHEMBL23364352 | 1.00 | MAPT (1.00) | MAPTSNCACRBNIKZF2WIZ | |
| SCHEMBL23386252 | 0.95 | MAPT (0.91) | MAPTSNCACRBNIKZF2WIZ | |
| SCHEMBL23386254 | 0.95 | MAPT (0.91) | MAPTSNCACRBNIKZF2WIZ | |
| SCHEMBL26513433 | 0.95 | MAPT (0.90) | MAPTSNCACRBNIKZF2WIZ | |
| SCHEMBL23386215 | 0.93 | MAPT (0.87) | MAPTSNCAIKZF2WIZ | |
| SCHEMBL26514012 | 0.93 | MAPT (0.87) | MAPTSNCACRBNIKZF2WIZ | |
| SCHEMBL23386225 | 0.93 | MAPT (0.86) | MAPTSNCACRBNIKZF2WIZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4337259-A1 | COMPOUNDS FOR DEGRADING ALPHA-SYNUCLEIN AGGREGATES AND USES THEREOF | Aprinoia Therapeutics Limited (HK) | 2024-03-20 | — | — | EP | disclosed |
| WO-2022238737-A1 | COMPOUNDS FOR DEGRADING ALPHA-SYNUCLEIN AGGREGATES AND USES THEREOF | APRINOIA THERAPEUTICS LIMITED (CN) | 2022-11-17 | — | — | WO | disclosed |
| EP-4058065-A1 | COMPOUNDS FOR DEGRADING TAU PROTEIN AGGREGATES AND USES THEREOF | Aprinoia Therapeutics Limited (HK) | 2022-09-21 | — | — | EP | disclosed |