Tranilast

Tranilast

SCHEMBL29875

COc1ccc(/C=C/C(=O)Nc2ccccc2C(=O)O)cc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 1.00
KMT2A Q03164 5/20 1.00
ALDH1A1 P00352 4/20 1.00
HPGD P15428 4/20 1.00
SMN1; SMN2 Q16637 4/20 1.00
NPC1 O15118 3/20 1.00
RAB9A P51151 3/20 1.00
NPSR1 Q6W5P4 3/20 1.00
TP53 P04637 2/20 1.00
CYP3A4 P08684 2/20 1.00
HIF1A Q16665 2/20 1.00
PKM P14618 2/20 1.00
KDM4E B2RXH2 2/20 1.00
CYP1A2 P05177 1/20 1.00
CYP2C9 P11712 1/20 1.00
CYP2C19 P33261 1/20 1.00
HSD17B10 Q99714 1/20 1.00
ABCC4 O15439 1/20 1.00
HPGDS O60760 1/20 1.00
ABCB11 O95342 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tranilast SCHEMBL8696829 1.00 MEN1 (1.00) MEN1KMT2AALDH1A1HPGDSMN1; SMN2
Tranilast SCHEMBL30053800 1.00 MEN1 (1.00) MEN1KMT2AALDH1A1HPGDSMN1; SMN2
Tranilast SCHEMBL10978582 1.00 MEN1 (1.00) MEN1KMT2AALDH1A1HPGDSMN1; SMN2
Tranilast SCHEMBL29366319 1.00 MEN1 (1.00) MEN1KMT2AALDH1A1HPGDSMN1; SMN2
Tranilast SCHEMBL29556872 1.00 MEN1 (1.00) MEN1KMT2AALDH1A1HPGDSMN1; SMN2
Tranilast SCHEMBL29876 1.00 MEN1 (1.00) MEN1KMT2AALDH1A1HPGDSMN1; SMN2
Tranilast SCHEMBL30352530 1.00 MEN1 (1.00) MEN1KMT2AALDH1A1HPGDSMN1; SMN2
Tranilast SCHEMBL1829087 0.99 MEN1 (0.98) MEN1KMT2AALDH1A1HPGDSMN1; SMN2
Tranilast SCHEMBL20770072 0.99 MEN1 (0.98) MEN1KMT2AALDH1A1HPGDSMN1; SMN2
Tranilast SCHEMBL10868728 0.99 MEN1 (0.98) MEN1KMT2AALDH1A1HPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 13778 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4731204-A2 SELECTIVE RBP4 ANTAGONIST AND C20-D3-RETINOL FOR TREATING MACULAR DEGENERATION, NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD), AND GOUTY ARTHRITIS (GOUT) The Trustees Of Columbia University In The City Of New York (US) 2026-04-29 EP claimed
US-20260091162-A1 SPRAYABLE POLYMERIC SCAFFOLD LOADED WITH INFLAMMASOME-INHIBITING LIPID NANORODS FOR ANTI-INFLAMMATION THERAPY KULKARNI ASHISH (US) 2026-04-02 US claimed
EP-4704971-A1 GAMMA STIMULATION AND NEUROMODULATOR COMBINATION THERAPY Cognito Therapeutics, Inc. (US) 2026-03-11 EP claimed
US-12569451-B2 Bio-inspired tissue-adhesive hydrogel patch and uses thereof Cellartgen Inc. (KR) 2026-03-10 US claimed
US-20260027230-A1 DRUG DELIVERY SYSTEM, TREATMENT KIT, AND METHOD FOR INHIBITING PROLIFERATION OR METASTASIS OF CANCER CELL CHINA MEDICAL UNIVERSITY (TW) 2026-01-29 US claimed
EP-4674894-A2 COPOLYMERS OF N-VINYLPYRROLIDONE WITH FUNCTIONALIZED MALEIC ACID MOIETIES Hemoteq AG (DE) 2026-01-07 EP claimed
US-20260000663-A1 RBP4 ANTAGONISTS FOR TREATMENT AND PREVENTION OF NON-ALCOHOLIC FATTY LIVER DISEASE AND GOUT THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2026-01-01 US claimed
US-20250381202-A1 PRODRUG KIT FOR MULTI-PRONGED CHEMOTHERAPY ZOUNEK ALEX (DE) 2025-12-18 US claimed
EP-4663688-A2 CROSSLINKERS Hemoteq AG (DE) 2025-12-17 EP claimed
US-20250375534-A1 COMPLEXES FOR DELIVERY OF NUCLEIC ACIDS BioNTech SE (DE) 2025-12-11 US claimed
EP-0588518-A1 Use of 2-(3,4-dimethoxycinnamoyl)-aminobenzoic acid for the manufacture of a medicament for the treatment of restenosis Kissei Pharmaceutical Co., Ltd. (JP) 1994-03-23 EP claimed
US-5288503-A WATER-PERMEABLE DIFFUSION BARRIER OF POLYVINYL ALCOHOL SRCHEM INCORPORATED (US) 1994-02-22 US claimed
US-5260066-A Cryogel bandage containing therapeutic agent SRCHEM INCORPORATED (US) 1993-11-09 US claimed
US-5087455-A HOLLOW GRANULAR MEDICINE AND ITS PREPARATION SHOWA YAKUHIN KAKO CO. LTD. (JP) 1992-02-11 US claimed
US-5051406-A Protein as a binder for drugs NIPPON HYPOX LABORATORIES INCORPORATED (JP) 1991-09-24 US claimed
EP-0391002-A2 Pharmaceutical compositions containing N-(3,4-dimethoxycinnamoyl) anthranilic acid KISSEI PHARMACEUTICAL CO., LTD. (JP) 1990-10-10 EP claimed
EP-0167825-A2 Lipid nano pellets as drug carriers for oral administration Dr. Rentschler Arzneimittel GmbH & Co. (DE) 1986-01-15 EP claimed
EP-0074725-B1 A METHOD FOR THE PRODUCTION OF NUCLEAR SUBSTITUTED CINNAMOYLANTHRANILIC ACID DERIVATIVES AND INTERMEDIATES THEREOF Kissei Pharmaceutical Co. Ltd. (JP) 1985-12-27 EP claimed
US-4486597-A Method for the production of nuclear substituted cinnamoylanthranilic acid derivatives KISSEI PHARMACEUTICAL CO., LTD. (JP) 1984-12-04 US claimed
EP-0074725-A1 A method for the production of nuclear substituted cinnamoylanthranilic acid derivatives and intermediates thereof Kissei Pharmaceutical Co. Ltd. (JP) 1983-03-23 EP claimed