Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 3/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24738873 | 1.00 | KLKB1 (0.34) | KLKB1FGFR4ALDH1A1ALOX15HSD17B10 | |
| SCHEMBL29879730 | 0.88 | KLKB1 (0.32) | KLKB1CYP3A4CYP2C9FGFR3CYP2C19 | |
| SCHEMBL29304491 | 0.88 | KLKB1 (0.32) | KLKB1CYP3A4CYP2C9FGFR3CYP2C19 | |
| SCHEMBL29302902 | 0.85 | KLKB1 (0.39) | KLKB1 | |
| SCHEMBL30997821 | 0.85 | KLKB1 (0.39) | KLKB1 | |
| SCHEMBL29879646 | 0.83 | KLKB1 (0.34) | KLKB1 | |
| SCHEMBL24737532 | 0.83 | KLKB1 (0.34) | KLKB1 | |
| SCHEMBL24739985 | 0.82 | PRCP (0.35) | KLKB1 | |
| SCHEMBL30997845 | 0.82 | PRCP (0.35) | KLKB1 | |
| SCHEMBL24739007 | 0.82 | KLKB1 (0.33) | KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308230-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197758-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |