Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 11/20 | 0.33 |
| ▸ | TRPM5 | Q9NZQ8 | 3/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.31 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27957777 | 1.00 | MAP4K1 (0.33) | MAP4K1TRPM5MAPK14KLKB1LPAR2 | |
| SCHEMBL29879590 | 1.00 | MAP4K1 (0.33) | MAP4K1TRPM5MAPK14KLKB1LPAR2 | |
| SCHEMBL29879582 | 1.00 | MAP4K1 (0.33) | MAP4K1TRPM5MAPK14KLKB1LPAR2 | |
| SCHEMBL29879320 | 0.91 | TYK2 (0.35) | TRPM5MAPK14 | |
| SCHEMBL29879289 | 0.91 | TYK2 (0.35) | TRPM5MAPK14 | |
| SCHEMBL24739003 | 0.91 | TYK2 (0.35) | TRPM5MAPK14 | |
| SCHEMBL29879801 | 0.91 | TYK2 (0.35) | TRPM5MAPK14 | |
| SCHEMBL29305522 | 0.90 | MAP4K1 (0.34) | MAP4K1TRPM5KLKB1 | |
| SCHEMBL29879619 | 0.90 | KCNH2 (0.31) | KLKB1 | |
| SCHEMBL24737650 | 0.90 | KCNH2 (0.31) | KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308230-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197758-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |