SCHEMBL29880992

SCHEMBL29880992

O=C(O)c1ccc2nn(-c3ccc(O)cc3O)nc2c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MYC P01106 2/20 0.44
PDK1 Q15118 2/20 0.42
PDK2 Q15119 2/20 0.42
PDK3 Q15120 2/20 0.42
PDK4 Q16654 2/20 0.42
TDP1 Q9NUW8 1/20 0.41
CA12 O43570 4/20 0.40
CA1 P00915 4/20 0.40
CA2 P00918 4/20 0.40
CA9 Q16790 4/20 0.40
CA6 P23280 3/20 0.40
CA7 P43166 3/20 0.40
CA14 Q9ULX7 3/20 0.40
CA4 P22748 2/20 0.40
KDM4E B2RXH2 2/20 0.40
GAA P10253 2/20 0.40
POLB P06746 1/20 0.40
MAPT P10636 1/20 0.40
PTGS2 P35354 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21630099 1.00 MYC (0.44) MYCPDK1PDK2PDK3PDK4
SCHEMBL21630095 0.85 KDM4E (0.49) MYCCA1CA2KDM4ETYR
SCHEMBL29881125 0.85 KDM4E (0.49) MYCCA1CA2KDM4ETYR
SCHEMBL17201891 0.84 NPC1 (0.42) KDM4EPOLBMAPTTYRALDH1A1
SCHEMBL9189375 0.84 POLB (0.47) MYCTDP1CA12CA1CA2
SCHEMBL2401376 0.83 MYC (0.51) MYCTDP1CA12CA1CA2
SCHEMBL21848040 0.81 MYC (0.47) MYCTDP1CA12CA1CA2
SCHEMBL28556638 0.79 NPC1 (0.40) POLBTYRNPC1RAB9AMEN1
SCHEMBL21630097 0.78 TP53 (0.54) TSHR
SCHEMBL29880666 0.78 TP53 (0.54) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110494425-B Benzotriazole derivative compound and use thereof 希普洛化成股份有限公司 2022-08-16 CN disclosed