Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 14/20 | 0.62 |
| ▸ | BRD2 | P25440 | 1/20 | 0.55 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.44 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.44 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.44 |
| ▸ | BAZ2B | Q9UIF8 | 2/20 | 0.43 |
| ▸ | BAZ2A | Q9UIF9 | 2/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28881169 | 1.00 | CREBBP (0.62) | CREBBPBRD2BRD3TP53SMARCA2 | |
| SCHEMBL28881533 | 0.92 | CREBBP (0.62) | CREBBPBRD2BRD3TP53SMARCA2 | |
| SCHEMBL29883537 | 0.90 | CREBBP (0.61) | CREBBPBRD2BRD3TP53SMARCA2 | |
| SCHEMBL28881208 | 0.90 | CREBBP (0.61) | CREBBPBRD2BRD3TP53SMARCA2 | |
| SCHEMBL28881538 | 0.87 | CREBBP (0.61) | CREBBPBRD2BRD3TP53SMARCA2 | |
| SCHEMBL28881166 | 0.86 | CREBBP (0.82) | CREBBPBRD2BRD3 | |
| SCHEMBL28881198 | 0.85 | CREBBP (0.58) | CREBBPBRD2BRD3TP53SMARCA2 | |
| SCHEMBL29882685 | 0.85 | CREBBP (0.56) | CREBBPBRD2BRD3TP53SMARCA2 | |
| SCHEMBL28616947 | 0.84 | CREBBP (0.66) | CREBBPBRD2BRD3TP53 | |
| SCHEMBL28605563 | 0.84 | CREBBP (0.66) | CREBBPBRD2BRD3SMARCA2SMARCA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111320621-B | Indolizine compound and preparation method and application thereof | 中国科学院广州生物医药与健康研究院 | 2022-10-04 | — | — | CN | disclosed |