Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 16/20 | 0.47 |
| ▸ | EGFR | P00533 | 8/20 | 0.47 |
| ▸ | FECH | P22830 | 2/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.38 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | MYH14 | Q7Z406 | 1/20 | 0.38 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24569646 | 1.00 | ERBB2 (0.47) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL24569329 | 0.94 | ERBB2 (0.46) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL29887800 | 0.94 | ERBB2 (0.46) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL29887979 | 0.91 | ERBB2 (0.49) | ERBB2EGFR | |
| SCHEMBL24569863 | 0.91 | ERBB2 (0.49) | ERBB2EGFR | |
| SCHEMBL24569620 | 0.88 | ERBB2 (0.52) | ERBB2EGFR | |
| SCHEMBL29887989 | 0.88 | ERBB2 (0.52) | ERBB2EGFR | |
| SCHEMBL24569813 | 0.88 | ERBB2 (0.52) | ERBB2EGFR | |
| SCHEMBL29887758 | 0.88 | ERBB2 (0.52) | ERBB2EGFR | |
| SCHEMBL24569302 | 0.87 | ERBB2 (0.50) | ERBB2EGFRFECHCDK8MAP2K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267137-A1 | LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 | Enliven Inc. (US) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022140769-A1 | LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 | ENLIVEN THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |