Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 0.50 |
| ▸ | PIM1 | P11309 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | LTK | P29376 | 1/20 | 0.47 |
| ▸ | GRK5 | P34947 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23415332 | 1.00 | PARP1 (0.50) | PARP1PIM1AURKADAPK3JAK2 | |
| SCHEMBL18395037 | 0.79 | PARP1 (0.47) | PARP1PIM1AURKADAPK3JAK2 | |
| SCHEMBL29888467 | 0.76 | KRAS (0.39) | MAP4K4SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL23464717 | 0.76 | KRAS (0.39) | MAP4K4SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL23465081 | 0.74 | MAP4K4 (0.49) | MAP4K4 | |
| SCHEMBL25779676 | 0.74 | SMN1; SMN2 (0.40) | MAP4K4SMN1; SMN2 | |
| SCHEMBL21415486 | 0.74 | PARP1 (0.51) | PARP1PIM1AURKADAPK3JAK2 | |
| SCHEMBL16637093 | 0.74 | PARP1 (0.47) | PARP1PIM1AURKADAPK3JAK2 | |
| SCHEMBL29810919 | 0.74 | PARP1 (0.47) | PARP1PIM1AURKADAPK3JAK2 | |
| SCHEMBL18128478 | 0.71 | IP6K1 (0.56) | PARP1PIM1AURKADAPK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114980976-A | Covalent RAS inhibitors and uses thereof | 锐新医药公司 | 2022-08-30 | — | — | CN | disclosed |