Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.35 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.35 |
| ▸ | CD38 | P28907 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24569933 | 1.00 | EGFR (0.38) | EGFRSMN1; SMN2MAPTHTTLMNA | |
| SCHEMBL24570035 | 0.87 | EGFR (0.37) | EGFRSMN1; SMN2MAPTHTTLMNA | |
| SCHEMBL29888044 | 0.87 | EGFR (0.37) | EGFRSMN1; SMN2MAPTHTTLMNA | |
| SCHEMBL24569937 | 0.87 | EGFR (0.37) | EGFRSMN1; SMN2MAPTHTTLMNA | |
| SCHEMBL24569302 | 0.84 | ERBB2 (0.50) | EGFRERBB2 | |
| SCHEMBL24569812 | 0.82 | EGFR (0.43) | EGFRSMN1; SMN2MAPTHTTLMNA | |
| SCHEMBL24569954 | 0.82 | HTT (0.55) | EGFRSMN1; SMN2MAPTHTTLMNA | |
| SCHEMBL26000095 | 0.81 | EGFR (0.45) | EGFRERBB2EIF2AK2 | |
| SCHEMBL24569953 | 0.80 | EGFR (0.44) | EGFRSMN1; SMN2MAPTHTTLMNA | |
| SCHEMBL29887934 | 0.80 | EGFR (0.44) | EGFRSMN1; SMN2MAPTHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267137-A1 | LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 | Enliven Inc. (US) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022140769-A1 | LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 | ENLIVEN THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |