Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 17/20 | 1.00 |
| ▸ | GRM5 | P41594 | 7/20 | 1.00 |
| ▸ | NPC1 | O15118 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | RAB9A | P51151 | 1/20 | 1.00 |
| ▸ | NFKB2 | Q00653 | 1/20 | 1.00 |
| ▸ | RELA | Q04206 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | MAOA | P21397 | 3/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2326572 | 1.00 | MAOB (1.00) | MAOBGRM5NPC1ALDH1A1HPGD | |
| SCHEMBL22451525 | 0.92 | MAOB (0.85) | MAOBGRM5NPC1ALDH1A1HPGD | |
| SCHEMBL6836955 | 0.89 | MAOB (0.81) | MAOBGRM5NPC1ALDH1A1HPGD | |
| SCHEMBL30353218 | 0.89 | MAOB (0.81) | MAOBGRM5NPC1ALDH1A1HPGD | |
| SCHEMBL23905149 | 0.87 | MAOB (0.77) | MAOBGRM5NPC1ALDH1A1HPGD | |
| SCHEMBL23905167 | 0.87 | MAOB (1.00) | MAOBGRM5NPC1ALDH1A1HPGD | |
| SCHEMBL281588 | 0.86 | MAOB (1.00) | MAOBGRM5NPC1ALDH1A1HPGD | |
| SCHEMBL23906031 | 0.85 | MAOB (0.74) | MAOBGRM5NPC1ALDH1A1HPGD | |
| SCHEMBL23906233 | 0.84 | MAOB (0.71) | MAOBGRM5NPC1ALDH1A1HPGD | |
| SCHEMBL16562137 | 0.82 | MAOB (0.69) | MAOBGRM5NPC1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115003295-B | Novel chroman derivatives having estrogen receptor degrading activity and uses thereof | 冰洲石生物科技公司 | 2025-05-06 | — | — | CN | disclosed |
| EP-4541795-A1 | AROMATIC COMPOUND, METHOD FOR PREPARING SAME, AND USE THEREOF IN PREPARATION OF ESTROGEN RECEPTOR DEGRADER | Hinova Pharmaceuticals Inc. (CN) | 2025-04-23 | — | — | EP | disclosed |
| WO-2024015409-A1 | CHROMAN DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-01-18 | — | — | WO | disclosed |
| CN-117229286-A | Aromatic compound, preparation method thereof and application thereof in preparation of estrogen receptor degradation agent | 海创药业股份有限公司 | 2023-12-15 | — | — | CN | disclosed |
| CN-110770211-B | Alpha, beta unsaturated amide compound | 协和麒麟株式会社 | 2023-09-19 | — | — | CN | disclosed |
| CN-111039916-B | Tricyclic spiro compounds | 小野药品工业株式会社 | 2023-04-28 | — | — | CN | disclosed |
| EP-4126835-A1 | INHIBITORS OF ANTIGEN PRESENTATION BY HLA-DR | Janssen Pharmaceutica NV (BE) | 2023-02-08 | — | — | EP | disclosed |
| CN-108430972-B | Alpha, beta-unsaturated amide compound | 协和麒麟株式会社 | 2022-12-27 | — | — | CN | disclosed |
| CN-115003295-A | Novel chroman derivatives having estrogen receptor degrading activity and uses thereof | 冰洲石生物科技公司 | 2022-09-02 | — | — | CN | disclosed |