Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE2 | Q9Y5Z0 | 20/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL297530 | 0.93 | BACE2 (0.64) | BACE2 | |
| SCHEMBL298686 | 0.92 | BACE2 (0.63) | BACE2 | |
| SCHEMBL298113 | 0.90 | BACE2 (0.60) | BACE2 | |
| SCHEMBL298543 | 0.90 | BACE2 (0.60) | BACE2 | |
| SCHEMBL297735 | 0.89 | BACE2 (0.59) | BACE2 | |
| SCHEMBL298283 | 0.88 | BACE2 (0.60) | BACE2 | |
| SCHEMBL298345 | 0.84 | BACE2 (0.62) | BACE2 | |
| SCHEMBL299094 | 0.84 | BACE2 (0.61) | BACE2 | |
| SCHEMBL298649 | 0.83 | BACE2 (0.63) | BACE2 | |
| SCHEMBL298280 | 0.82 | BACE2 (0.59) | BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427437-A1 | DIHYDROPYRIMIDINONES FOR USE AS BACE2 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |